Can microRNA become next-generation tools in molecular diagnostics and therapeutics? A systematic review

Abstract Background MicroRNAs (miRNAs) represent a novel class of single-stranded RNA molecules 18–22 nucleotides that serve as powerful tools in the regulation gene expression. They are important regulatory several biological processes. Main body Alteration expression profiles miRNAs have been found diseases. It is anticipated miRNA profiling can become diagnostic tool future. Hence, this review evaluates implications various diseases and recent advances level detection their target identification. A systematic approach to existing literature available on databases such Medline, PubMed, EMBASE was conducted better understanding mechanisms mediating miRNA-dependent role markers therapeutic agents. Conclusion clear complex multilevel prerequisite explicate origin wide variety understandable offer potential targets both diagnostics therapeutics multitude The inclusion specific biomarkers may lead crucial advancements facilitating disease diagnosis classification, monitoring its prognosis, treatment. However, standardization methods has pivotal success extensive use routine clinical settings.